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1.
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.
Mol Cell
; 66(1): 154-162.e10, 2017 Apr 06.
Article
in English
| MEDLINE | ID: mdl-28344083
2.
Regression of castration-resistant prostate cancer by a novel compound QW07 targeting androgen receptor N-terminal domain.
Cell Biol Toxicol
; 36(5): 399-416, 2020 10.
Article
in English
| MEDLINE | ID: mdl-32002708
3.
Diastereoselective synthesis of 3,3-disubstituted 3-nitro-4-chromanone derivatives as potential antitumor agents.
Org Biomol Chem
; 17(5): 1062-1066, 2019 01 31.
Article
in English
| MEDLINE | ID: mdl-30638240
4.
SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance.
Mol Pharmacol
; 91(5): 464-474, 2017 05.
Article
in English
| MEDLINE | ID: mdl-28213589
5.
Maslinic acid induces mitochondrial apoptosis and suppresses HIF-1α expression in A549 lung cancer cells under normoxic and hypoxic conditions.
Molecules
; 19(12): 19892-906, 2014 Nov 28.
Article
in English
| MEDLINE | ID: mdl-25460312
6.
Synthesis of Heterocyclic Ring-Fused Bisnoralcohol Derivatives as Novel Small-Molecule Antiosteoporosis Agents.
J Med Chem
; 2024 May 08.
Article
in English
| MEDLINE | ID: mdl-38717088
7.
A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened.
Cell Chem Biol
; 2024 Feb 28.
Article
in English
| MEDLINE | ID: mdl-38442710
8.
Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20(S)-Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents.
J Med Chem
; 66(17): 11965-11984, 2023 09 14.
Article
in English
| MEDLINE | ID: mdl-37597216
9.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
Bioorg Med Chem Lett
; 22(23): 7237-42, 2012 Dec 01.
Article
in English
| MEDLINE | ID: mdl-23067554
10.
Synthesis of plant-derived cholesterol from bisnoralcohol.
Steroids
; 178: 108967, 2022 02.
Article
in English
| MEDLINE | ID: mdl-35085676
11.
Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol.
Eur J Med Chem
; 236: 114323, 2022 Jun 05.
Article
in English
| MEDLINE | ID: mdl-35397399
12.
Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate.
Cell Res
; 32(3): 288-301, 2022 03.
Article
in English
| MEDLINE | ID: mdl-35121857
13.
Targeting STAT3 by a small molecule suppresses pancreatic cancer progression.
Oncogene
; 40(8): 1440-1457, 2021 02.
Article
in English
| MEDLINE | ID: mdl-33420372
14.
Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one.
Steroids
; 157: 108600, 2020 05.
Article
in English
| MEDLINE | ID: mdl-32068080
15.
Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
Bioorg Med Chem Lett
; 19(23): 6618-22, 2009 Dec 01.
Article
in English
| MEDLINE | ID: mdl-19846303
16.
Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potential antiproliferative agents for castration-resistant prostate cancer.
RSC Adv
; 9(58): 33794-33799, 2019 Oct 18.
Article
in English
| MEDLINE | ID: mdl-35528914
17.
Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents.
Eur J Med Chem
; 176: 21-40, 2019 Aug 15.
Article
in English
| MEDLINE | ID: mdl-31091478
18.
Discovery of methylpyrimidine ring-fused diterpenoid analogs as a novel testosterone synthesis promoter.
RSC Adv
; 9(17): 9709-9717, 2019 Mar 22.
Article
in English
| MEDLINE | ID: mdl-35520707
19.
Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinaseâ 2 (LRRK2) in Parkinson's Disease.
ChemMedChem
; 14(17): 1580-1585, 2019 09 04.
Article
in English
| MEDLINE | ID: mdl-31365783
20.
A facile synthesis of ursodeoxycholic acid and obeticholic acid from cholic acid.
Steroids
; 140: 173-178, 2018 12.
Article
in English
| MEDLINE | ID: mdl-30389306